Rabbit vs. Mouse
Monoclonal Antibodies

Advantages of Rabbit Monoclonals

  • More diverse epitope recognition
  • Improved immune response to small-size epitopes
  • High specificity and affinity
  • Greatly improved response to mouse antigens

Rabbit Monoclonal Antibodies (RabMAbs) provide the combined benefits of superior antigen recognition of the rabbit immune system with the specificity and consistency of a monoclonal antibody, bringing you the highest quality antibody possible.

Rabbit vs. Mouse References

The reliability of rabbit monoclonal antibodies in the immunohistochemical assessment of estrogen receptors, progesterone receptors, and HER2 in human breast carcinomas. Rhodes A, Sarson J, Assam EE, Dean SJ, Cribb EC, Parker A. [Am J Clin Pathol. 2010 Oct;134(4):621-32]

Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2.Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. [PLoS One. 2008;3(12):e4069. Epub 2008 Dec 31]

Rabbit monoclonal antibodies show higher sensitivity than mouse monoclonals for estrogen and progesterone receptor evaluation in breast cancer by immunohistochemistry. Rocha R, Nunes C, Rocha G, Oliveira F, Sanches F, Gobbi H. [Pathol Res Pract, 2008;204(9):655-62. Epub 2008 Jun 18]

Comparative analysis of six different antibodies against Her2 including the novel rabbit monoclonal antibody (SP3) and chromogenic in situ hybridisation in breast carcinomas. Nunes CB, Rocha RM, Reis-Filho JS, Lambros MB, Rocha GF, Sanches FS, Oliveira FN, Gobbi H. [J Clin Pathol. 2008 Aug;61(8):934-8. Epub 2008 May 12]

Rabbit monoclonal antibodies: a comparative study between a novel category of immunoreagents and the corresponding mouse monoclonal antibodies. Rossi S, Laurino L, Furlanetto A, Chinellato S, Orvieto E, Canal F, Facchetti F, Dei Tos AP. [Am J Clin Pathol. 2005 Aug;124(2):295-302]

A comparison between the novel rabbit monoclonal antibodies (SP1 and B644) and mouse antibodies for evaluating estrogen receptor in breast tumors. Rafael Malagoli Rocha1; Cristiana Buzelin Nunes, Gislene Fátima Silva Rocha, Flávio Nepomuceno Oliveira, Fernanda Squárcio Fernandes Sanches, Helenice Gobbi [J Bras Patol Med Lab. 2007;143(6):435-440]

A new rabbit monoclonal antibody (4B5) for the immunohistochemical (IHC) determination of the HER2 status in breast cancer: comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility. Powell WC, Hicks DG, Prescott N, Tarr SM, Laniauskas S, Williams T, Short S, Pettay J, Nagle RB, Dabbs DJ, Scott KM, Brown RW, Grogan T, Roche PC, Tubbs RR. [Appl Immunohistochem Mol Morphol. 2007 Mar;15(1):94-102]

Immunohistochemical Detection Using the New Rabbit Monoclonal Antibody SP1 of Estrogen Receptor in Breast Cancer Is Superior to Mouse Monoclonal Antibody 1D5 in Predicting Survival. Maggie C.U. Cheang, Diana O. Treaba, Caroline H. Speers, Ivo A. Olivotto, Chris D. Bajdik, Stephen K. Chia, Lynn C. Goldstein, Karen A. Gelmon, David Huntsman, C. Blake Gilks, Torsten O. Nielsen, Allen M. Gown [Journal of Clinical Oncology, Vol 24, No 36 (December 20), 2006: pp. 5637-5644]


To evaluate the specificity and sensitivity of Epitomics' RabMAbs, we compared various diagnostic marker specific RabMAbs with the leading commercially available Mouse Monoclonal counterparts. Both antibodies were tested on the same formalin fixed paraffin-embedded tissue sample and under their recommended immunohistochemistry conditions.

The results shown below demonstrate that Epitomics' RabMAbs have higher sensitivity combined with lower background than the comparable mouse monoclonal antibodies. In conclusion, Epitomics RabMAbs are proving to be exceptional affinity reagents for the detection of key diagnostic and prognostic markers in formalin fixed and paraffin embedded (FFPE) tissue sample.


See NordiQC Antibody Comparison

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RabMAb Technology

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See below for IHC Comparison images - on Formalin fixed, paraffin-embedded Human tissue


Name Catalog # Applications
CDX2 2475-1 WB, IHC, ICC, FC

Paraffin-embedded human colonic carcinoma tissue stained with Epitomics' CDX2 RabMAb (Cat# 2475-1) and Vendor A's CDX2 Mouse Monoclonal (both at 1:1000 dilution factor)

Cathepsin D

Name Catalog # Applications
Cathepsin D 2487-1 WB, IHC, ICC
Cathepsin D 2431-1 WB, IHC, FC, IP
Cathepsin D Pro 2510-1 WB

Paraffin-embedded human breast ductal infiltrating carcinoma tissue stained with Epitomics' Cathepsin D RabMAb (Cat# 2510-1, at 1:500 dilution factor) and Vendor A's Cathepsin D Mouse Monoclonal (at 1:50 dilution factor)


Name Catalog # Applications
E-Cadherin 1702-1 WB, IHC, ICC, IP
E-Cadherin (pS838/840) 2239-1 WB, IHC, ICC, IP

Paraffin-embedded human breast carcinoma tissue stained with Epitomics' E-Cadherin RabMAb (Cat# 1702-1, at 1:500 dilution factor) and Vendor A's E-Cadherin Mouse Monoclonal (at 1:50 dilution factor).


Name Catalog # Applications
Her2 2064-1 WB, IHC, FC, IP
Her2 4201-1 IHC
Her2 (pY877) 2265-1 WB, ICC
Her2 (p1139) 1991-1 WB, FC, IP

Paraffin-embedded human breast carcinoma tissue stained with Epitomics' Her2 RabMAb and Vendor A's Her2 Mouse Monoclonal (both at 1:500 dilution factor).


Name Catalog # Applications
MCM5 2380-1 WB, IHC, ICC, FC, IP
MCM5 2374-1 WB, IHC, ICC, FC, IP

Paraffin-embedded human brain glioma tissue stained with Epitomics' MCM5 RabMAb (Cat# 2374-1) and Vendor A's MCM5 Mouse Monoclonal (both at 1:500 dilution factor)