Survivin DyLight^® 488 (BIRC5) antibody RabMAb®

Cat.#: 4520-1
Abcam ID: ab139847

Rabbit Monoclonal Antibody

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Description

Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family that interferes with post-mitochondrial events including activation of caspases. Survivin regulates cell cycle and is expressed in most tumors, but it is barely detectable in the terminally differentiated normal cells and tissues. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target (1). Survivin is expressed in the G2/M phase of the cell cycle. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis (2).

Recommended Applications

ICC

Applications and Recommended Dilution Factors

ICC: 1:50 - 1:100

Species Reactivity *

Human

*DyLight is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

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Products Data

Immunofluorescent analysis of Hela cells labeled with anti-Survivin RabMAb (DyLight 488 conjugate, green) and dapi (blue).

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Specificity

A synthetic peptide corresponding to residues on the N terminus of human Survivin was used as an immunogen.

Storage Condition and Buffer

Supplied in PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Store at 4℃. Protect from light. Stable for 6 months from date of receipt.

Alternative Names

BIRC5 antibody, API4 antibody, EPR-1 antibody, Baculoviral IAP repeat-containing protein 5 antibody, Apoptosis inhibitor 4 antibody, Apoptosis inhibitor survivin antibody

Description References

1. Sah N.K. et al. Cancer Letters 244(2):164-171, 2006 2. Li F, et al. Nature 396(6711):580-4, 1998

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