SOX2 DyLight® 488 antibody RabMAb®Cat.#: 4522-1
Abcam ID: ab139849
Rabbit Monoclonal Antibody
Swiss Prot: P48431
Mol Weight: 35kDa
Price: Contact Abcam
SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach (1). SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression (2).
Applications and Recommended Dilution Factors
ICC: 1:50 - 100
Species Reactivity *
*DyLight is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
|Immunofluorescent analysis of A) NCCIT (positive control) and B) HeLa (negative control) cells using anti-SOX2 RabMAb (DyLight 488 conjugate, green) and Dapi (blue).|
A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen.
Storage Condition and Buffer
Supplied in PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Store at 4℃. Protect from light. Stable for 6 months from date of receipt.
SOX2 antibody, ANOP3 antibody, MCOPS3 antibody, Transcription factor SOX-2 antibody
1. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins. Pruitt KD, Tatusova, T, Maglott DR. Nucleic Acids Res. 2007 Jan 1;35(Database issue):D61-5 2. Masui S, et al. Nat Cell Biol. 9(6):625-35, 2007
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