RSK1 Phospho (pT573) (RPS6KA1) antibody 
RabMAb®
Cat.#: 2185-1
Rabbit Monoclonal Antibody
Swiss Prot: Q15418
Mol Weight: 90kDa
Price: $285
Availability: Ship next business day
Description
RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:100 - 250
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data
 |
| A. Western blot analysis on K562 cell lysates using anti-Phospho-Rsk-1 (pT573) RabMAb (cat. #2185-1), 1:500 dilution. Cells were either (A) untreated or (B) treated with TPA. |
Specificity
A phospho specific peptide corresponding to residues surrounding Threonine 573 of human RSK-1 was used as an immunogen. This antibody detects RSK-1 phosphorylated at Threonine 573.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
RPS6KA1 antibody, HU-1 antibody, MAPKAPK1A antibody, RSK antibody, RSK1 antibody, Ribosomal protein S6 kinase alpha-1 antibody, Ribosomal S6 kinase 1 antibody
Description References
1. Dalby, K.N. et al. J. Biol. Chem. 273, 1496-1505 (1998).
2. Frodin, M. and Gammeltoft, S. Mol. Cell. Endocrinol. 151, 65
3. Lazar, D. F. et al. J. Biol. Chem. 270, 20801
4. Chen, R. et al. Proc. Natl. Acad. Sci. USA, 90, 10952
Product References
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