CD11b/ITAM (ITGAM) antibody 
RabMAb®
Cat.#: 1936-1
Rabbit Monoclonal Antibody
Swiss Prot: P11215
Mol Weight: 170kDa
Price: $260
Availability: Ship next business day
Description
Integrin alpha-M (ITAM, ITGAM, CD11b, MAC-1 alpha subunit, CR3 alpha chain) is the alpha subunit of ITAM/beta-2 complex (CD11b/CD18, Mac-1), a leukocyte adhesion heterodimeric glycoprotein (1). ITAM belongs to integrin alpha chain family and it is predominately presented in human myeloid cells, NK1 cells, monocytes, and granulocytes. ITAM/beta-2 complex is a receptor for fibrinogen (binding to P1 and P1 peptides of gamma chain), factor X, and ICAM1. ITAM/beta-2 is implicated in adhesive interactions of monocytes, macrophages, and granulocytes. It is also linked to mediation of complement-coated particle uptake (2).
Recommended Applications
WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100-1:250
ICC: 1:100-1:250
IP: 1:80
FC: 1:20
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data
 |  |
| A. Western blot analysis on TF-1 cell lysate using anti-CD11b/ITAM RabMAb (cat. #1936-1). | B. Immunohistochemical analysis of paraffin-embedded human spleen using anti-ITAM RabMAb (cat. # 1936-1). |
Specificity
A synthetic peptide corresponding to C-terminus of human CD11b/ITAM protein was used as immunogen
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
ITGAM antibody, CD11B antibody, CR3A antibody, MAC-1 antibody, MAC1A antibody, MGC117044 antibody, MO1A antibody, SLEB6 antibody, Integrin alpha-M antibody, CD11 antigen-like family member B antibody, CR-3 alpha chain antibody, Cell surface glycoprotein MAC-1 subunit alpha antibody, Leukocyte adhesion receptor MO1 antibody, Neutrophil adherence receptor antibody
Description References
1. Corbi AL et al. J. Biol. Chem. 263(25):12403-12411, 1
2. Barden A et al. Clin Sci (Lond). 92(1):37-44m 1997.
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