Btk (C-term) (BTK) antibody 
RabMAb®
Cat.#: 1599-1
Rabbit Monoclonal Antibody
Swiss Prot: Q06187
Mol Weight: 77kDa
Price: $260
Availability: Ship next business day
Description
Btk (Bruton tyrosine kinase also known as BPK or ATK) is a member of the TEC family of non-receptor protein tyrosine kinase which includes Bmx, Itk and TEC. Btk is composed of a pleckstrin domain, an SH3 and SH2 domain, a catalytic kinase domain and a TEC homology domain (1). BTK plays a crucial role in B cell activation and development (2). Similar to Etk-TNFR2 interaction, Btk interacts with Fas, a member of the TNFR family involved in apoptosis in a ligand-independent manner (3). Mutations in the Btk gene have been linked to severe developmental blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia (XLA). Patients with this disease are unusually prone to bacterial infection but not to viral infection.
Recommended Applications
WB, IP
Applications and Recommended Dilution Factors
WB: 1:500
IP: 1:20
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data
 |
| A. Western blot analysis on Daudi cell lysate using anti-Btk (C-term) RabMAb (cat. #1599-1), 1:500 dilution |
Specificity
A synthetic peptide corresponding to residues in the C-term of human Btk was used as immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
BTK antibody, AGMX1 antibody, AT antibody, ATK antibody, BPK antibody, IMD1 antibody, MGC126261 antibody, MGC126262 antibody, PSCTK1 antibody, XLA antibody, Tyrosine-protein kinase BTK antibody, Bruton tyrosine kinase antibody
Description References
1. Tsukada, S., Saffaran, D., Rawlings, D. & Witte, O. (1993) Cell 72, 279-290
2. Rawlings, D. J. & Witte, O. N. (1995) Semin. Immunol. 7, 237-246
3. Vassilev, A., Z. Ozer, C. Navara, S. Mahajan, and F. M. Uckun. 1999. J. Biol. Chem. 274:1646-1656
4. Yun Qiu, Dan Robinson, Tom G. Pretlow, and Hsing-Jien Kung, Cell Biology, Vol. 95, Issue 7, 3644-3649, March 31, 1998
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