Bcl-10 (BCL10) antibody RabMAb®

Cat.#: 1680-1
Abcam ID: ab40752

Rabbit Monoclonal Antibody

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Description

Bcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1-2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptormediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3-4). Defects in Bcl-10 have been identified in various types of cancer.

Recommended Applications

WB, IP, FC

Applications and Recommended Dilution Factors

WB: 1:500-2,000
IP: 1:30
FC: 1:20

Species Reactivity *

Human

*Cross reactivity determined by western blot only.

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Products Data

A. Western blot analysis on Raji cell lysate using anti-Bcl-10 RabMAb (cat. # 1680-1), dilution 1:2,000.

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Specificity

A synthetic peptide corresponding to residues near the N-term of human Bcl-10 was used as immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

BCL10 antibody, CARMEN antibody, CIPER antibody, CLAP antibody, c-E10 antibody, mE10 antibody, B-cell lymphoma/leukemia 10 antibody, Mammalian CARD-containing adapter molecule E10 antibody

Description References

1. Wotherspoon, A. C.; Pan, L. X.; Diss, T. C.; Isaacson, P. G. : Cancer Genet. Cytogenet. 58: 35-38, 1992
2. Zhang, Q. et al. 1999.Nat. Genet. 22:63-68
3. Ruland, J. et al. 2001. Cell. 104:33-42.
4. Ruefli-Brasse et al. Science. 302:1581-1584

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