Phospho-MYC-T58 Antibody
Cat.#: T3831Rabbit Polyclonal Antibody
Swiss Prot: P01106
Mol Weight: 50kDa
Price: $289*
Availability: Ship 4-5 business days
Description
MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
Recommended Applications
WB, ELISA
Applications and Recommended Dilution Factors
WB: 1:50~200
ELISA: 1:1,000
Species Reactivity
Human
Products Data
 |
| Dot blot analysis of Phospho-MYC-T58 Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. |
Specificity
This Phospho-MYC-T58 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T58 of human MYC.
Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein A affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Names
MYC antibody, MRTL antibody, bHLHe39 antibody, c-Myc antibody, Myc proto-oncogene protein antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody
Description References
Qi, Y., et al., Nature 431(7009):712-717 (2004).
Wilda, M., et al., Genes Chromosomes Cancer 41(2):178-182 (2004).
Dom, et al., Oncogene 23(44):7378-7390 (2004).
Pap, T., et al., Arthritis Rheum. 50(9):2794-2802 (2004).
Ozawa, N., et al., Endocrinology 145(9):4244-4250 (2004).
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