Beta-Synuclein (SNCB) antibody RabMAb®

Cat.#: 1977-1
Abcam ID: ab76111

Rabbit Monoclonal Antibody

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Bulk and Custom formulation available Email request

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Description

The Beta-Synuclein protein is highly homologous to the alpha-synuclein protein for which two mutations were reported in some familial cases of Parkinson disease. It has been shown that both alpha- and beta-synucleins may be able to inhibit phospholipase D2 selectively (1). Recent studies have shown that the neurodegenerative process in disorders with Lewy body formation, such as Parkinson's disease and dementia with Lewy bodies, is associated with alpha-synuclein accumulation and that beta-synuclein might protect the central nervous system from the neurotoxic effects of alpha-synuclein (2). results raise the possibility that beta-synuclein might be a natural negative regulator of alpha-synuclein aggregation and that a similar class of endogenous factors might regulate the aggregation state of other molecules involved in neurodegeneration. Such an anti-amyloidogenic property of beta-synuclein might also provide a novel strategy for the treatment of neurodegenerative disorders (3).

Recommended Applications

WB, IHC, ICC, IP

Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250
IP: 1:40

Species Reactivity *

Human, Mouse, Rat

*Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only

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Products Data

A. Western blot analysis on fetal brain lysate using anti-beta synuclein RabMAb (cat. # 1977-1), dilution 1:10,000.	B. Immunohistochemical staining of paraffin-embedded human brain using anti-Beta-Synuclein RabMAb (cat. #1977-1).	C. Immunofluorescent staining of PC12 cells using anti-Beta-Synuclein RabMAb (cat. #1977-1).

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Specificity

A synthetic peptide corresponding to residues near the N-terminus of human Beta Synuclein was used as an immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

SNCB antibody, Beta-synuclein antibody

Description References

1. Lavedan C, et al. Genomics 54(1):173-5, 1998
2. Hashimoto M, et al. J Biol Chem 279(22):23622-9, 2004
3. Hashimoto M, et al. Neuron 32(2):213-23, 2001

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