MMP-2 (MMP2) antibody RabMAb®

Cat.#: 1948-1
Abcam ID: ab51125

Rabbit Monoclonal Antibody

---

Download datasheet [PDF]|Similar Products|Related Products

Bulk and Custom formulation available Email request

---

Description

The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumor invasion and tumour spread. MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme (1). MMP2 is regulated differently from other MMPs, suggesting that it may play a unique role in cell-matrix interactions, including cell invasion. The conversion from the 72 kDa progelatinase A to the active 62 kDa species may be a key event in the acquisition of invasive potential(2)

Recommended Applications

WB

Applications and Recommended Dilution Factors

WB: 1:1000-10,000

Species Reactivity *

Human, Mouse, Rat

*Cross reactivity determined by western blot only.

---

Products Data

A. Western blot analysis on 1 ng recombinant protein using anti-MMP-2 RabMAb (cat. # 1948-1), dilution 1:1000.

---

Specificity

A synthetic peptide corresponding to residues on human MMP-2 was used as an immunogen. This antibody detects both the pro- and active forms of MMP-2.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

MMP2 antibody, CLG4 antibody, CLG4A antibody, MMP-II antibody, MONA antibody, TBE-1 antibody, PEX antibody, TBE-1 antibody

Description References

1. Murray GI, et al. J Pathol, 185(3):256-61
2. Yu, AE, et al. Biochem Cell Biol, 74(6):823-31, 1996

Product References

1. Eiseler T, Döppler H, Yan IK, et al, Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion ,Breast Cancer Res. 11 (2009) R13

Similar Products

Product Name	Catalog #
MMP-2 (propeptide) RabMAb®	2008-1
MMP-2 RabMAb®	2763-1

Related Products

Product Name	Catalog #
Goat Anti-Rabbit IgG (H+L) HRP	3053-1
Goat Anti-Rabbit IgG polymerized HRP	3051-1
Cell Lysis Buffer	3500-1
Goat Anti-Rabbit IgG HRP Antibody	3056-1