IDO (IDO1) antibody RabMAb®

Cat.#: 2121-1
Abcam ID: ab76157

Rabbit Monoclonal Antibody

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Bulk and Custom formulation available Email request

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Description

T lymphocytes undergo proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3-dioxygenase (IDO), an enzyme that is expressed in placenta and catalyzes tryptophan degradation. Here we show that most human tumors constitutively express IDO. Results suggest that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor (1). Certain macrophages, induced to express IDO in response to interferon-gamma and other signals from activating T cells, inhibit T-cell proliferation in vitro by rapidly consuming tryptophan. Because IDO is also expressed by human syncytiotrophoblast cells and systemic tryptophan concentration falls during normal pregnancy, it is believed that IDO expression at the maternal-fetal interface is necessary to prevent immunologic rejection of the fetal allografts (2).

Recommended Applications

WB

Applications and Recommended Dilution Factors

WB: 1:1000 - 10,000

Species Reactivity *

Human

*Cross reactivity determined by western blot only.

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Products Data

A. Fig 1. Western blot analysis on Hela + IFN-gamma cell lysate using anti-IDO RabMAb (cat. # 2121-1), dilution 1:5000.

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Specificity

A synthetic peptide corresponding to residues within human IDO was used as an immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

IDO1 antibody, IDO antibody, IDO-1 antibody, INDO antibody, Indoleamine 2,3-dioxygenase 1 antibody, Indoleamine-pyrrole 2,3-dioxygenase antibody

Description References

1. Uyttenhove C, et al. Nat Med 9(10):1269-74, 2003
2. Munn, et al. Science 281(5380):1191-3, 1998

Product References

1. De Ravin SS, Zarember KA, Long-Priel D, et al, Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease ,Blood 116 (2010) 1755-1760

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