Cbl Phospho (pY731) (CBL) antibody 
RabMAb®
Cat.#: 1873-1
Rabbit Monoclonal Antibody
Swiss Prot: P22681
Mol Weight: 120kDa
Price: $285*
Availability: Ship next business day
Description
c-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4).
Recommended Applications
WB, IP
Applications and Recommended Dilution Factors
WB: 1:1000 - 2000
IP: 1:50
Species Reactivity *
Human, Mouse, Rat
*Cross reactivity determined by western blot only.
Products Data
 |
| A. Western blot analysis on Raji cell lysates using anti-Phospho-c-Cbl (pY731) RabMAb (cat. #1873-1), 1:2000 dilution. Cells were either (A) untreated (B) treated with pervanadate |
Specificity
A synthetic phospho-peptide corresponding to residues surrounding Tyr731 of human Cbl was used as immunogen. The antibody detects Cbl phosphorylated on Tyrosine 731.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
CBL antibody, C-CBL antibody, CBL2 antibody, RNF55 antibody, E3 ubiquitin-protein ligase CBL antibody, Casitas B-lineage lymphoma proto-oncogene antibody, Proto-oncogene c-Cbl antibody, RING finger protein 55 antibody, Signal transduction protein CBL antibody
Description References
1. Langdon, WY, et al. Proc. Natl. Acad. Sci. 86:1168
2. Blake, TJ, et al. EMBO J. 12:2017
3. Joazeiro, CA, et al. Science 286:309
4. Galisteo, ML, et al. J. Biol. Chem. 270: 20242
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