Her2 DyLight^® 488 (ERBB2) antibody RabMAb®

Cat.#: 4527-1
Abcam ID: ab139854

Rabbit Monoclonal Antibody

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Description

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Recommended Applications

FC

Applications and Recommended Dilution Factors

FC: 1:50

Species Reactivity

Human

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Products Data

Flow cytometric analysis of SKBR-3 cells using ErbB2/Her2 RabMAb (DyLight 488 conjugate) (red) compared to nonspecific negative control antibody (green).

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Specificity

A synthetic peptide corresponding to residues near the C-terminus of human Her2 was used as an immunogen. This antibody detects Her2 phosphorylated at Tyr1248 as well as unphosphorylated Her2.

Storage Condition and Buffer

Supplied in PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Store at 4℃. Protect from light. Stable for 6 months from date of receipt.

Alternative Names

ERBB2 antibody, CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Receptor tyrosine-protein kinase erbB-2 antibody, Proto-oncogene Neu antibody, Proto-oncogene c-ErbB-2 antibody, Tyrosine kinase-type cell surface receptor HER2 antibody, p185erbB2 antibody

Description References

1. Muthuswamy, S. K., et al. Mol. Cell. Biol. 19: 6845-6857 (1999). 2. Qian, X., et al. Proc. Natl. Acad. Sci. USA 91: 1500-1504 (1994). 3. Dittadi, R, et al. J. Natl. Cancer Inst. 92: 1443-1444 (2000). 4. Klapper, L. N., et al. Cancer Res. 60: 3384-3388 (2000). DyLight is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

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