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PKC antibody

Cat.#: S2234

Rabbit Polyclonal Antibody

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Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq]

Recommended Applications

WB

Applications and Recommended Dilution Factors

WB: 1:500-1:3000

Species Reactivity *

Human

*Other species have not been tested

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Products Data

Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE diluted at 1:1000

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Specificity

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 220 of Human PRKCA

Storage Condition and Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.

Alternative Names

PRKCA antibody, AAG6 antibody, PKC-alpha antibody, PKCA antibody, PRKACA antibody, Protein kinase C alpha type antibody

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