RAF1 antibody
Cat.#: S2099Rabbit Polyclonal Antibody
Swiss Prot: P04049
Mol Weight: 73.06kDa
Price: $289*
Availability: Ship 4-5 business days
Description
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq]
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:500-1:3000
Species Reactivity *
Human
*Other species have not been tested
Products Data
 |
| Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE diluted at 1:5000 |
Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 51 and 347 of human RAF1
Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.
Alternative Names
RAF1 antibody, CRAF antibody, NS5 antibody, Raf-1 antibody, c-Raf antibody, RAF proto-oncogene serine/threonine-protein kinase antibody, Raf-1 antibody
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