c-Myc antibody
Cat.#: S1242Rabbit Polyclonal Antibody
Swiss Prot: P01106
Mol Weight: 50.57kDa
Price: $289*
Availability: Ship 4-5 business days
Description
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]
Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1:500-1:3000
ICC:
Species Reactivity *
Human, Mouse
*Other species have not been tested
Products Data
 |  |
| Sample (30 ug of whole cell lysate) A: NIH-3T3 10% SDS PAGE c-Myc antibody diluted at 1:1000 | Sample(30 ug whole cell lysate) A:MOLT4 10% SDS PAGE diluted at 1:1000 |
Specificity
Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 37 of c-Myc
Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.
Alternative Names
MYC antibody, MRTL antibody, bHLHe39 antibody, c-Myc antibody, Myc proto-oncogene protein antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody
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