ABAT antibody RabMAb®

Cat.#: 3359-1
Abcam ID: ab108249

Rabbit Monoclonal Antibody

---

Download datasheet [PDF]|Related Products

Bulk and Custom formulation available Email request

---

Description

ABAT (4-aminobutyrate aminotransferase) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities (1).

Recommended Applications

WB, IHC, IP

Applications and Recommended Dilution Factors

WB: 1:10,000 - 50,000
IHC: 1:250 - 500
IP: 1:10 - 100

Species Reactivity *

Human, Mouse, Rat

*For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only

---

Products Data

Western blot analysis on (A) HepG2, (B) SH-SY5Y, (C) fetal liver, (D) rat brain, (E) rat kidney, and (F) mouse brain lysates using anti-ABAT RabMAb (cat. #3359-1).	Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ABAT RabMAb (cat. #3359-1).

---

Specificity

A synthetic peptide corresponding to residues in human ABAT was used as an immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

ABAT antibody, GABA-AT antibody, GABAT antibody, NPD009 antibody, 4-aminobutyrate aminotransferase, mitochondrial antibody, L-AIBAT antibody

Description References

1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1; 33: D54-8.

Related Products

Product Name	Catalog #
Goat Anti-Rabbit IgG (H+L) HRP	3053-1
Goat Anti-Rabbit IgG polymerized HRP	3051-1
Cell Lysis Buffer	3500-1
Goat Anti-Rabbit IgG HRP Antibody	3056-1