ABAT antibody RabMAb®Cat.#: 3359-1
Abcam ID: ab108249
Rabbit Monoclonal Antibody
Swiss Prot: P80404
Mol Weight: 50kDa
ABAT (4-aminobutyrate aminotransferase) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities (1).
WB, IHC, IP
Applications and Recommended Dilution Factors
WB: 1:10,000 - 50,000
IHC: 1:250 - 500
IP: 1:10 - 100
Species Reactivity *
Human, Mouse, Rat
*For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only
A synthetic peptide corresponding to residues in human ABAT was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
ABAT antibody, GABA-AT antibody, GABAT antibody, NPD009 antibody, 4-aminobutyrate aminotransferase, mitochondrial antibody, L-AIBAT antibody
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1; 33: D54-8.
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