GSK-3β (C-term) DyLight® 488 (GSK3B) antibody 
RabMAb®
Cat.#: 4525-1
Rabbit Monoclonal Antibody
Swiss Prot: P49841
Mol Weight: 46kDa
Price: $275*
Availability: Ship next business day
Description
Glycogen synthase kinase 3 beta (GSK-3β) is a Serine/Threonine protein kinase involved in the insulin and wingless pathways (1-2). Originally identified as a regulator of glycogen synthase, it has been shown to regulate a diverse array of cellular functions. GSK-3β activity is down regulated by phosphorylation on Serine 9 by PKB, or activated by phosphorylation on Tyrosine 216. Once activated, the protein can phosphorylate p53, c-jun, heat shock factor-1 and cyclin D1 (3-4). It is also known to phosphorylate Tau in Alzheimer's disease. Additionally, increased GSK-3β protein levels are found in Alzheimer's disease brains.
Recommended Applications
ICC
Applications and Recommended Dilution Factors
ICC: 1:100
Species Reactivity
Human
Products Data
 |
| Immunofluorescent analysis of A431 cells using GSK-3 beta (C-term) RabMAb (DyLight 488 conjugate) (green) and Dapi (blue). |
Specificity
A synthetic peptide corresponding to residues in the C-term of human GSK-3β was used as immunogen. This antibody may detect splice isoform 2 based on sequence homology.
Storage Condition and Buffer
Supplied in PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Store at 4℃. Protect from light. Stable for 6 months from date of receipt.
Alternative Names
GSK3B antibody, - antibody, Glycogen synthase kinase-3 beta antibody, antibody
Description References
1. Plyte SE, Hughes K, Nikolakaki E, Pulverer BJ, Woodgett JR. Biochim Biophys Acta. 1992 Dec 16; 1114(2-3):147-162. 2. Miller, J. R. & Moon, R. T. (1996) Genes Dev. 10, 2527-2539 3. Boyle WJ, Smeal T, Defize LH, Angel P, Woodgett JR, Karin M, Hunter T. Cell. 1991 Feb 8;64(3):573-584. 4. Bellacosa, A., Testa, J. R., Staal, S. P. & Tsichllis, P. N. (1992) Science 254, 244-247 DyLight is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
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