Bad (N-term) DyLight® 488 (BAD) antibody 
RabMAb®
Cat.#: 4509-1
Rabbit Monoclonal Antibody
Swiss Prot: Q92934
Mol Weight: 23kDa
Price: $275*
Availability: Ship next business day
Description
Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.
Recommended Applications
FC
Applications and Recommended Dilution Factors
FC: 1:50
Species Reactivity *
Human
*DyLight is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Products Data
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| Flow cytometric analysis of Hela cells using Bad RabMAb (DyLight 488 conjugate) (red) compared to a negative control antibody (green). |
Specificity
A synthetic peptide corresponding to residues in the N-term of human Bad was used as immunogen. The antibody does not cross-react with other Bcl-2 members.
Storage Condition and Buffer
Supplied in PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Store at 4℃. Protect from light. Stable for 6 months from date of receipt.
Alternative Names
BAD antibody, BBC2 antibody, BCL2L8 antibody, Bcl2 antagonist of cell death antibody, Bcl-XL/Bcl-2-associated death promoter antibody
Description References
1. Greider, C.W., and Blackburn, E.H. (1985). Cell 43, 405-413 2. Feng J, Funk WD, Wang SS, et al. Science 1995; 269:1236-41 3. Greider, C.W. (1996). Annu. Rev. Biochem. 65, 337-365 4. Shay JW, Cacchetti SA, Eur J Cancer. 1997:33:787-791
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