CD8 (CD8A) antibody 
RabMAb®
Cat.#: 2519-1
Rabbit Monoclonal Antibody
Swiss Prot: P01732
Mol Weight: 32kDa
Price: $260*
Availability: Ship next business day
Description
The T cell coreceptor CD8 is a cell-surface glycoprotein expressed either as a disulfide-linked homodimer of two CD8 alpha monomers, or a heterodimer of CD8 alpha and CD8 beta. These receptors interact with ligands, such as major histocompatibility complex (MHC) class I, on the outside of the cell, with proteins inside the cell, such as the tyrosine kinase p56lck, and possibly with proteins on the same cell-surface (1). CD8 plays an important role in T cell development in the thymus and T cell activation in the periphery (2).
Recommended Applications
WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 5,000
IHC: 1:250 - 500
ICC: 1:100 - 250
IP: 1:10
FC: 1:40
Species Reactivity
Human
Products Data
 |  |
| Western blot analysis on A) MOLT-4, B) Jurkat cell lysates using anti-CD8 RabMAb (cat. # 2519-1). | Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD8 RabMAb (cat. # 2519-1). |
Specificity
A synthetic peptide corresponding to residues near the C-terminus of human CD8 Alpha chain was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
CD8A antibody, CD8 antibody, Leu2 antibody, MAL antibody, p32 antibody, T-cell surface glycoprotein CD8 alpha chain antibody, T-lymphocyte differentiation antigen T8/Leu-2 antibody
Description References
1. Devine L, et al. Immunol Res, 19(2-3):201-10, 1999. 2. Wong, JS, et al. J Immunol 171:867-874, 2003
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