IL-1 beta (C-term) (IL1B) antibody 
RabMAb®
Cat.#: 1630-1
Rabbit Monoclonal Antibody
Swiss Prot: P01584
Mol Weight: 17kDa
Price: $220
Availability: Ship next business day
Description
Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn's disease which makes IL1 beta an important target for this disease (4).
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data
 |
| A. Western blot analysis of anti-IL1 beta RabMAb (cat. # 1630-1), dilution 1:5,000. (approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane) |
Specificity
A synthetic peptide corresponding to residues in the C-terminus of human IL1-beta was used as immunogen
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
IL1B antibody, IL-1 antibody, IL1-BETA antibody, IL1F2 antibody, Interleukin-1 beta antibody, Catabolin antibody
Description References
1. March et al. Nature 315: 641-647, 1985.
2. Dinarello, C. A. (1996) Blood 87, 2095-2147
3. Yuan et al. Cell 75, 641-652, 1993
4. Shin Maeda et al. Science 4 February 2005: 734-738.
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