JAK3 antibody RabMAb®

Cat.#: 2856-1
Abcam ID: ab92595

Rabbit Monoclonal Antibody

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Bulk and Custom formulation available Email request

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Description

JAK3 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors; upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5).

Recommended Applications

WB, ICC

Applications and Recommended Dilution Factors

WB: 1:1,000-10,000
ICC: 1:250 - 500

Species Reactivity

Human

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Products Data

Western blot analysis on (A) IM-9 and (B) TF-1 cell lysates using anti-JAK3 RabMAb (cat. # 2856-1).

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Specificity

A synthetic peptide corresponding to residues on the N-terminus in human JAK3 was used as an immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

JAK3 antibody, JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, Tyrosine-protein kinase JAK3 antibody, Leukocyte janus kinase antibody

Description References

1. Leonard WJ et al. Annu Rev Immunol. 16:293-322, 1998. 2. Vaysberg M et al. Am J Transplant. 9(10):2292-302, 2009. 3. Malabarba M et al. J Biol Chem, 270:9630-9637, 1995. 4. Cornejo MG et al. Blood. 113(12):2746-54, 2009. 5. Pesu M et al. Immunol Rev. 203:127-42, 2005.

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