CD11b/ITAM (ITGAM) antibody 
RabMAb®
Cat.#: 2729-1
Rabbit Monoclonal Antibody
Swiss Prot: P11215
Mol Weight: 170kDa
Price: $260*
Availability: Ship next business day
Description
Integrin alpha-M (ITAM, ITGAM, CD11b, MAC-1 alpha subunit, CR3 alpha chain) belongs to integrin alpha chain family and it is predominately presented in human myeloid cells, NK1 cells, monocytes, and granulocytes. The alpha subunit of ITAM/beta-2 complex (CD11b/CD18, Mac-1), is a receptor for fibrinogen (binding to P1 and P1 peptides of gamma chain), factor X, and ICAM1. ITAM/beta-2 is implicated in adhesive interactions of monocytes, macrophages, and granulocytes. It is also linked to mediation of complement-coated particle uptake (2).
Recommended Applications
WB, IHC, ICC, FC
Applications and Recommended Dilution Factors
WB: 1:1000 - 5000
IHC: 1:100 - 250
ICC: 1:100 - 250
FC: 1:100
Species Reactivity *
Human
*For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only
Products Data
 |  |  |
| Western blot analysis on (A) THP-1 +TPA (B) TF-1 cell lysates using anti-CD11b RabMAb (cat. #2729-1). | Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD11b RabMAb (cat. #2729-1). | Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD11b RabMAb (cat. #2729-1). |
Specificity
A synthetic peptide corresponding to residues in human CD11b was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
ITGAM antibody, CD11B antibody, CR3A antibody, MAC-1 antibody, MAC1A antibody, MGC117044 antibody, MO1A antibody, SLEB6 antibody, Integrin alpha-M antibody, CD11 antigen-like family member B antibody, CR-3 alpha chain antibody, Cell surface glycoprotein MAC-1 subunit alpha antibody, Leukocyte adhesion receptor MO1 antibody, Neutrophil adherence receptor antibody
Description References
1. Corbi AL et al. J. Biol. Chem. 263(25):12403-12411, 1988 2. Barden A et al. Clin Sci (Lond). 92(1):37-44m 1997
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