SOX2 antibody 
RabMAb®
Cat.#: 2683-1
Rabbit Monoclonal Antibody
Swiss Prot: P48431
Mol Weight: 35kDa
Price: $260*
Availability: Ship next business day
Description
SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach (1). SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression (2).
Recommended Applications
WB, IHC, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:50 - 100
Species Reactivity *
Human, Mouse
*Species cross-reactivity is based on WB analysis.
Products Data
 |  |  |
| Western blot analysis on (A) NCCIT and (B) MCF-7 cell lysates using anti-SOX2 RabMAb (cat. #2683-1). | Positive immunohistochemical staining of paraffin-embedded glioma tissue using anti-SOX2 RabMAb (cat. #2683-1). | Negative immunohistochemical staining of paraffin-embedded human adult brain tissue using anti-SOX2 RabMAb (cat. #2683-1). |
 | ||
| Positive immunohistochemical staining of paraffin-embedded human fetal brain tissue using anti-SOX2 RabMAb (cat. #2683-1). |
Specificity
A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
SOX2 antibody, ANOP3 antibody, MCOPS3 antibody, MGC2413 antibody, Transcription factor SOX-2 antibody, antibody
Description References
1. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins. Pruitt KD, Tatusova, T, Maglott DR. Nucleic Acids Res. 2007 Jan 1;35(Database issue):D61-5 2. Masui S, et al. Nat Cell Biol. 9(6):625-35, 2007
Similar Products
| Product Name | Catalog # |
|---|---|
| SOX2 RabMAb® | 2696-1 |
| SOX2 DyLight® 488 RabMAb® | 4522-1 |
| SOX2 antibody | S0731 |
| SOX2 antibody | S0900 |
Related Products
| Product Name | Catalog # |
|---|---|
| Goat Anti-Rabbit IgG (H+L) HRP | 3053-1 |
| Goat Anti-Rabbit IgG polymerized HRP | 3051-1 |
| Cell Lysis Buffer | 3500-1 |
| Goat Anti-Rabbit IgG HRP Antibody | 3056-1 |
| Goat Anti-Rabbit IgG DyLight® 405 | 3063-1 |
| Goat Anti-Rabbit IgG DyLight® 488 | 3064-1 |
| Goat Anti-Rabbit IgG DyLight® 550 | 3065-1 |
| Goat Anti-Rabbit IgG DyLight® 594 | 3066-1 |
| Goat Anti-Rabbit IgG DyLight® 633 | 3067-1 |
| Goat Anti-Rabbit IgG DyLight® 650 | 3068-1 |
