Tau Phospho (pS356) (MAPT) antibody RabMAb®

Cat.#: 2699-1
Abcam ID: ab92682

Rabbit Monoclonal Antibody

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Bulk and Custom formulation available Email request

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Description

Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).

Recommended Applications

WB, ICC

Applications and Recommended Dilution Factors

WB: 1:5,000 - 10,000
ICC: 1:100 - 250

Species Reactivity

Human

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Products Data

Western blot analysis on SH-SY5Y cell lysates using anti-Phospho-Tau (pS356) RabMAb (cat. #2699-1). Cells were either (A) untreated (B) treated with Okadaic Acid and Calyculin A.

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Specificity

A phospho-specific peptide corresponding to residues surrounding Serine 356 of human Tau was used as an immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

MAPT antibody, DDPAC antibody, FTDP-17 antibody, MAPTL antibody, MSTD antibody, MTBT1 antibody, MTBT2 antibody, PPND antibody, TAU antibody, Microtubule-associated protein tau antibody, Neurofibrillary tangle protein antibody, Paired helical filament-tau antibody

Description References

1. Goedert, M., et al. Proc Natl Acad Sci U S A. 85: 4051
2. Jakes, R., et al. EMBO J. 10: 2725
3. Maas, T., et al. J Biol Chem. 275: 15733
4. Singh, T.J., et al. Arch. Biochem. Biophys. 328: 43

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