Ferritin (heavy chain) (FTH1) antibody 
RabMAb®
Cat.#: 2444-1
Rabbit Monoclonal Antibody
Swiss Prot: P02794
Mol Weight: 21kDa
Price: $260*
Availability: Ship next business day
Description
Ferritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains, and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1-2). Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristic of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3). Microfilaments and increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway, supporting a possible physiological mechanism for the release of ferritin from the liver (4).
Recommended Applications
WB, IHC
Applications and Recommended Dilution Factors
WB: 1:500 - 2000
IHC: 1:100 - 250
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data
 |  |
| A. Western blot analysis on (A) human liver, (B) SH-SY5Y, (C) human brain, (D) human brain, and (E) HeLa cell lysates using anti-Ferritin (heavy chain) RabMAb (cat. # 2444-1), dilution (A-C) 1:500, (D) 1:2000 and (E) 1:5000. | B. Immunohistochemical analysis of paraffin-embedded human kidney using anti-Ferritin (heavy chain) RabMAb (cat. #2444-1). |
Specificity
A synthetic peptide corresponding to residues near the C terminus of human Ferritin (heavy chain) was used as an immunogen. This antibody recognizes only the Ferritin heavy chain.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alternative Names
FTH1 antibody, FHC antibody, FTH antibody, FTHL6 antibody, MGC104426 antibody, PIG15 antibody, PLIF antibody, Ferritin heavy chain antibody, Cell proliferation-inducing gene 15 protein antibody
Description References
1. Boyd D, et al. Proc Natl Acad Sci U S A. 81(15):4751-5, 1984
2. Lawson DM, et al. Nature. 349(6309):541-4, 1991
3. Zandman-Goddard G, et al. Autoimmunity Reviews 6(7):457-463, 2007
4. Ramm G A, et al. Hepatology 19(2): 504-513, 2005
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