ORP1 (OSBPL1A) antibody RabMAb®Cat.#: 5984-1
Abcam ID: ab131165
Rabbit Monoclonal Antibody
Swiss Prot: Q9BXW6
Mol Weight: 50 - 108kDa
ORP1 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain (1). ORP1 binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Three ORP1 isoforms have been reported (isoform A: 50 kDa, isoform B: 108 kDa, isoform C: 106 kDa) (2).
WB, IP, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IP: 1:10 - 100
FC: 1:10 - 100
Species Reactivity *
Human, Mouse, Rat
*Species cross-reactivity is based on WB analysis.
|Western blot analysis on (A) A549, (B) 293T, and (C) U87-MG cell lysates using anti-ORP1 RabMAb (cat. #5984-1).||Flow cytometric analysis of permeabilized A549 cells using anti-ORP1 RabMAb (red) (cat. # 5984-1) or a rabbit IgG (negative) (green).|
A synthetic peptide corresponding to residues on the C-terminus of human ORP1 was used as an immunogen.
Storage Condition and Buffer
Store at -20° C. Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
OSBPL1A antibody, ORP-1 antibody, ORP1 antibody, OSBPL1B antibody, Oxysterol-binding protein-related protein 1 antibody
1. Entrez Gene: gene-centered information at NCBI.
Nucleic Acids Res. 2005 Jan 1;33:D54-8.
2. The UniProt Consortium Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
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