ORP1 (OSBPL1A) antibody RabMAb®

Cat.#: 5984-1
Abcam ID: ab131165

Rabbit Monoclonal Antibody

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Bulk and Custom formulation available Email request

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Description

ORP1 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain (1). ORP1 binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Three ORP1 isoforms have been reported (isoform A: 50 kDa, isoform B: 108 kDa, isoform C: 106 kDa) (2).

Recommended Applications

WB, IP, FC

Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IP: 1:10 - 100
FC: 1:10 - 100

Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

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Products Data

Western blot analysis on (A) A549, (B) 293T, and (C) U87-MG cell lysates using anti-ORP1 RabMAb (cat. #5984-1).	Flow cytometric analysis of permeabilized A549 cells using anti-ORP1 RabMAb (red) (cat. # 5984-1) or a rabbit IgG (negative) (green).

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Specificity

A synthetic peptide corresponding to residues on the C-terminus of human ORP1 was used as an immunogen.

Storage Condition and Buffer

Store at -20° C. Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

OSBPL1A antibody, ORP-1 antibody, ORP1 antibody, OSBPL1B antibody, Oxysterol-binding protein-related protein 1 antibody

Description References

1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.
2. The UniProt Consortium Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

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