USP39 antibody RabMAb®

Cat.#: 5934-1
Abcam ID: ab131244

Rabbit Monoclonal Antibody

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Bulk and Custom formulation available Email request

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Description

USP39 (U4/U6.U5 tri-snRNP-associated protein 2) is involved in the assembly of the spliceosome, the RNA splicing machinery. The spliceosome consists of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5 and U6 as well as a large number of non-snRNP proteins. It is essential for the recruitment of tri-snRNP to the pre-spliceosome and is known as a tri-snRNP-specific protein. USP39 is also a deubiquitinating enzyme, but it lacks protease activity due to absence of key active-site residues cysteine and histidine (1).

Recommended Applications

WB, IHC, ICC

Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250

Species Reactivity *

Human, Mouse

*Species cross-reactivity is based on WB analysis.

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Products Data

Western blot analysis on (A) HeLa, (B) 293T, (C) K562, and (D) Jurkat cell lysates using anti-USP39 RabMAb (cat. #5934-1).	Immunohistochemical analysis of paraffin-embedded human colonic adenocarcinoma tissue using anti-USP39 RabMAb (cat.# 5934-1).	Immunofluorescent staining of HeLa cells using anti-USP39 RabMAb (cat.# 5934-1).

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Specificity

A synthetic peptide corresponding to residues in human USP39 was used as an immunogen.

Storage Condition and Buffer

Store at -20° C. Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

USP39 antibody, 65K antibody, HSPC332 antibody, SAD1 antibody, SNRNP65 antibody, U4/U6.U5 tri-snRNP-associated protein 2 antibody, Inactive ubiquitin-specific peptidase 39 antibody, SAD1 homolog antibody, U4/U6.U5 tri-snRNP-associated 65 kDa protein antibody

Description References

1. Ríos Y et al. PLoS Genet. 2011 Jan 13;7(1):e1001271.

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