Dachshund1 (DACH1) antibody RabMAb®

Cat.#: 2476-1
Abcam ID: ab77234

Rabbit Monoclonal Antibody

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Bulk and Custom formulation available Email request

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Description

Dachshund is a human homologue of Drosophila melanogaster dachshund, which is a nuclear factor essential for determining cell fates in the eye, leg, and nervous system. Mouse Dachshund protein was immunolocalized to specific cell types within the developing kidneys, eyes, cochleae, and limb buds (1). Dachshund was found to be expressed in breast cancer cell lines and to inhibit transforming growth factor-beta (TGF-beta)-induced apoptosis. Dachshund participates in the negative regulation of TGF-beta signaling by interacting with NCoR and Smad4 (2).

Recommended Applications

WB, IP, FC

Applications and Recommended Dilution Factors

WB: 1:500 - 1000
IP: 1:40
FC: 1:120

Species Reactivity *

Human, Mouse

*Cross reactivity determined by western blot only.

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Products Data

A. Western blot analysis on (A) MCF-7 and (B) HeLa cell lysate using anti-Dachshund1 RabMAb (cat. # 2476-1), dilution 1:1000.

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Specificity

A synthetic peptide corresponding to residues near the C-terminus of human Dachshund1 was used as an immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

DACH1 antibody, DACH antibody, Dachshund homolog 1 antibody

Description References

1. Ayres JA, et al. Genomics 77(1-2):18-26, 2001
2. Wu K, et al. J Biol Chem 278(51):51673-84, 2003

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