SARA (ZFYVE9) antibody RabMAb®

Cat.#: 3898-1
Abcam ID: ab124875

Rabbit Monoclonal Antibody

---

Download datasheet [PDF]|Related Products

Bulk and Custom formulation available Email request

---

Description

SARA is a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. SARA functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of SARA interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor (1).

Recommended Applications

WB, IHC, IP, FC

Applications and Recommended Dilution Factors

WB: 1:10,000 - 50,000
IHC: 1:100 - 250
IP: 1:10 - 100
FC: 1:10 - 100

Species Reactivity *

Human, Rat

*Cross reactivity determined by western blot only.

---

Products Data

Western blot analysis on (A) human heart, (B) A673, (C) HT-1080, and (D) BxPC-3 cell lysates using anti-SARA RabMAb (cat. #3898-1).	Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SARA RabMAb (cat. #3898-1).	Western blot analysis on (A) Jurkat, (B) HeLa, and (C) fetal brain lysates using anti-SARA RabMAb (cat. #3898-1).

---

Specificity

A synthetic peptide corresponding to residues at the N-terminus of human SARA was used as an immunogen.

Storage Condition and Buffer

Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Alternative Names

ZFYVE9 antibody, MADHIP antibody, NSP antibody, SARA antibody, SMADIP antibody, Zinc finger FYVE domain-containing protein 9 antibody, Smad anchor for receptor activation antibody

Description References

1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1; 33: D54-8.

Related Products

Product Name	Catalog #
Goat Anti-Rabbit IgG (H+L) HRP	3053-1
Goat Anti-Rabbit IgG polymerized HRP	3051-1
Cell Lysis Buffer	3500-1
Goat Anti-Rabbit IgG HRP Antibody	3056-1