SARA (ZFYVE9) antibody RabMAb®Cat.#: 3898-1
Abcam ID: ab124875
Rabbit Monoclonal Antibody
Swiss Prot: O95405
Mol Weight: 180kDa
SARA is a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. SARA functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of SARA interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor (1).
WB, IHC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:10,000 - 50,000
IHC: 1:100 - 250
IP: 1:10 - 100
FC: 1:10 - 100
Species Reactivity *
*Cross reactivity determined by western blot only.
A synthetic peptide corresponding to residues at the N-terminus of human SARA was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
ZFYVE9 antibody, MADHIP antibody, NSP antibody, SARA antibody, SMADIP antibody, Zinc finger FYVE domain-containing protein 9 antibody, Smad anchor for receptor activation antibody
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1; 33: D54-8.
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