Rabbit Monoclonal Antibody | Product Data Sheet
|Quantity: 100ul||Lot #: Please refer to vial|
|Clone ID: EPR5373||Molecular Wt.: 50 kDa|
|Species Cross-reactivity* +Human+Mouse-Rat||UniProt ID: P05121|
Background: PAI-1 is a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the protein product are associated with thrombophilia (1).
Specificity: A synthetic peptide corresponding to residues in human PAI-1 was used as an immunogen.
Storage Condition and Buffer: Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
WB: 1:1,000 - 10,000
IP: 1:10 - 100
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1; 33: D54-8.
*Species cross-reactivity is based on WB analysis.
Fig 1. Western blot analysis on (A) fetal lung, (B) RAW 264.7, (C) HepG2, and (D) HT-1080 cell lysates using anti-PAI-1 RabMAb (cat. #3917-1).