Clone ID: EPR2560Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 2299-1
Size: 100
Price: $ 250
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| A. Western blot analysis on (A) rat brain lysate using anti-SOD2 RabMAb, dilution 1:2000. (B)SH-SY5Y lysate using anti-SOD2 RabMAb
(cat. # 2299-1), dilution 1:500. |
B. Immunohistochemical analysis of paraffin-embedded human liver using anti-SOD2 RabMAb (cat. #2299-1). |
Recommended Applications: WB, IHC
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 25 kDa
UniProt ID: P04179
Alternative names:
Description: Superoxide dismutase comprises a family of metalloenzymes that catalyze the oxido-reduction of superoxide anion to H2O2. Manganese superoxide dismutase (SOD2) is encoded by nuclear chromatin, synthesized in the cytosol, and imported posttranslationally into the mitochondrial matrix (1). It has been shown that SOD2 activity in tumor cells is lower than that in their normal counterparts. results suggest that the reduced level of SOD2 activity observed in human tumor cells is not due to a defect in the primary structure of the SOD2 protein, a change in the dosage of the SOD2 gene, or a decrease in the stability of SOD2 mRNA in tumor cells but rather is due to a defect or defects in the expression of the gene (2). SOD2 is one of the major cellular defense enzymes that protects against toxic effects of superoxide radicals. Overexpression of human SOD2 has been shown to inhibit radiation-induced neoplastic transformation, suppress malignancy of cancer cells, and increase tolerance to various toxic agents (3). Specificity: A synthetic peptide corresponding to residues near the N-terminus of human SOD2 was used as an immunogen.
Recommended Dilutions:
WB: 1:1000
IHC: 1:100 - 250
Protocols for using Epitomics Rabbit Monoclonal Antibodies
Description References:
| 1. |
Wispe JR, et al. Biochim Biophys Acta 994(1):30-6, 1989 |
| 2. |
St. Clair DK et al. Cancer Res 51(3):939-43, 1991 |
| 3. |
Wan XS, et al. DNA Cell Biol 13(11):1127-36 |
Orders:
877-772-2622 (US and Canada)
650-583-6688 (Domestic and International)
orders@epitomics.com
Technical Support: support@epitomics.com
Product MSDS: view page or download PDF
*Determined species reactivity – for other species not listed cross reactivity
may be possible but not tested. |
