Clone ID: EP2417Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 2264-1
Size: 100
Price: $ 285
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| A. Western blot analysis on human spleen lysate using anti- Integrin β-3A RabMAb (cat. # 2264-1), dilution 1:2000. |
B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Integrin beta3 (CD61) RabMAb. (cat. #2264-1). |
Recommended Applications: WB, IHC
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 110 kDa
UniProt ID: P05106
Alternative names: Platelet membrane glycoprotein IIIa, GPIIIa, CD61 antigen
Description: Platelet membrane glycoprotein Integrin β-3 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. A biochemically and immunologically similar membrane glycoprotein complex is present on endothelial cells. Homology suggests that GP IIIa is a member of a family of cell-surface adhesion receptors. (1) Data provide further support for the key role of the cytoplasmic domain of the beta3 integrin in cell adhesion and suggest a potential role for the beta3C integrin subunit in modulating cell-matrix interactions (2). It has been demonstrated that the beta 3 subunit of alpha IIb beta 3 was phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3). Specificity: A synthetic peptide corresponding to residues near C-terminus (the cytoplasmic region) of human Integrin β-3A was used as an immunogen. This antibody does not detect Integrin β-3B or Integrin β-3C.
Recommended Dilutions:
WB: 1:1000
IHC: 1:100
Protocols for using Epitomics Rabbit Monoclonal Antibodies
Description References:
| 1. |
Fitzgerald LA, et al. J Biol Chem 262(9):3936-9, 1987 |
| 2. |
Kumar CS, et al. J Biol Chem 272(26):16390-7, 1997 |
| 3. |
Law DA, et al. J Biol Chem 271(18):10811-5, 1996 |
Orders:
877-772-2622 (US and Canada)
650-583-6688 (Domestic and International)
orders@epitomics.com
Technical Support: support@epitomics.com
Product MSDS: view page or download PDF
*Determined species reactivity – for other species not listed cross reactivity
may be possible but not tested. |
