Clone ID: EP1402Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 2188-1
Size: 100ul
Price: $ 210
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| A. Western blot analysis on Ramos cell lysate using anti-PLCγII RabMAb (cat. # 2188-1), dilution 1:2000. |
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Recommended Applications: WB
Species Reactivity: Human
Mol. Weight: 150 kDa
UniProt ID: P16885
Alternative names: Phosphoinositide phospholipase C, PLC-gamma-2, Phospholipase C-gamma-2, PLC-IV
Description: Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. The phospholipase C gamma-2 (PLCγII) is an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important because of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate (1). PLCγII has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLCγII (2). It has also been shown that PLCγII was required for receptor activator of NF-kappaB ligand-induced (RANKL-induced) osteoclastogenesis by differentially regulating nuclear factor of activated T cells c1 (NFATc1), activator protein-1 (AP1), and NF-kappaB (3). Specificity: A synthetic peptide corresponding to residues near the C-terminus of human PLCγII was used as an immunogen.
Recommended Dilutions:
WB: 1:1000 - 2000
Protocols for using Epitomics Rabbit Monoclonal Antibodies
Description References:
| 1. |
Argeson AC, et al. Genomics 25(1):29-35, 1995. |
| 2. |
Ozdener F, et al. Mol Pharmacol 62(3):672-9, 2002. |
| 3. |
Mao D, et al. J Clin Invest 166(11):2869-79, 2006. |
Orders:
877-772-2622 (US and Canada)
650-583-6688 (Domestic and International)
orders@epitomics.com
Technical Support: support@epitomics.com
Product MSDS: view page or download PDF
*Determined species reactivity – for other species not listed cross reactivity
may be possible but not tested. |
