Clone ID: EP2067Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 2123-1
Size: 100ul
Price: $ 250
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A. Western blot analysis on
human brain lysate using
anti-ACHR-beta RabMAb
(cat. # 2123-1), dilution 1:1000. |
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Recommended Applications: WB, ICC, FC
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 56 kDa
UniProt ID: P11230
Alternative names:
Description: The nicotinic acetylcholine receptor controls electrical signaling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. The gate is a constricting hydrophobic girdle at the middle of the lipid bi-layer, formed by weak interactions between neighboring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore (1). The widespread distribution of the beta subunit suggests it may serve as a common subunit in different AChR combinations in various brain regions. Regulation of the expression of beta subunit appears to be relatively unrestrained, with an apparent excess of protein synthesized in the cytoplasm relative to that which ultimately arrives at functional targets in the plasma membrane (2). Specificity: A synthetic peptide corresponding to residues in the extracellular region of human Acetylcholine receptor subunit beta was used as an immunogen.
Recommended Dilutions:
WB: 1:1000 2000
ICC: 1:100
Flow Cytometry: 1:30
Protocols for using Epitomics Rabbit Monoclonal Antibodies
Description References:
| 1. |
Miyazawa A, et al. Nature 423(6943):949-55, 2003 |
| 2. |
Hill JA, et al. J Neurosci 13: 1551-68, 1993 |
Orders:
877-772-2622 (US and Canada)
650-583-6688 (Domestic and International)
orders@epitomics.com
Technical Support: support@epitomics.com
Product MSDS: view page or download PDF
*Determined species reactivity – for other species not listed cross reactivity
may be possible but not tested. |
