Clone ID: Y31
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 2031-1
Size: 100ul
Price: $ 250
Recommended Applications: WB, IHC, ICC
Species Reactivity: Human, Mouse
Mol. Weight: 40-50 kDa
UniProt ID: P51677
Alternative names: C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193 antigen
Description: CKR3, or C-C chemokine receptor type 3, is a G protein-coupled, seven-transmembrane domain receptor protein. The chemokine eotaxin appears to be a highly specific agonist for CKR3, making CKR3 one of the factors responsible for selective recruitment of eosinophils to sites of inflammation (1). It has been shown that more than one chemokine activates CKR3, including eotaxin, RANTES, and MCP-3 (2). Since CKR3 is prominently expressed in eosinophils , it has been named the human eosinophil eotaxin receptor (2,3). Specificity: A synthetic peptide corresponding to residues in C-terminal cytoplasmic domain of human CKR3 was used as immunogen. Predicted to cross-react with macaque, based on sequence homology.
Recommended Dilutions:
WB: 1:500
IHC: 1:100
ICC: 1:500
Protocols for using Epitomics Rabbit Monoclonal Antibodies
|
 |
| A. Western
blot analysis on (1) K562 and (2) Daudi cell lysates using anti-CCR3/CKR3
(C-term) RabMAb (catalog #2031-1), dilution 1:500. |
B. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CKR3/CCR3 (C-term) RabMAb (catalog #2031-1). |
Description References:
| 1. |
Combadiere, C., et al. Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270: 16491 |
| 2. |
Daugherty, B.L., et al. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med. 183: 2349 |
| 3. |
Ponath, P.D., et al. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med. 183: 2437 |
Orders:
877-772-2622 (US and Canada)
650-583-6688 (Domestic and International)
orders@epitomics.com
Technical Support: support@epitomics.com
Product MSDS: view page or download PDF
*Determined species reactivity – for other species not listed cross reactivity
may be possible but not tested. |
