Clone ID: E4
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 2004-1
Size: 100ul
Price: $ 250
Recommended Applications: WB, IHC, ICC, IP, FC
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 83 kDa
UniProt ID: Q15418
Alternative names: S6K-alpha 1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, Ribosomal S6 kinase 1, RSK-1, pp90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPKAPK1A
Description: RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4). Specificity: A synthetic peptide corresponding to residues in N-terminus of human p90-RSK1 was used as immunogen.
Recommended Dilutions:
WB: 1:1000
IHC: 1:100
ICC: 1:200
Flow Cytometry: 1:50
IP: 1:10
Protocols for using Epitomics Rabbit Monoclonal Antibodies
Product References:
| 1. | Mizutani T, Fukushi S, Saijo M, et al, Regulation of p90RSK phosphorylation by SARS-CoV infection in Vero E6 cells ,FEBS Letters 580 (2006) 1417?1424
[Application: WB] |
Description References:
| 1. |
Dalby, K.N. et al. Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90rsk That Are Inducible by MAPK. J. Biol. Chem. 273, 1496-1505 (1998) |
| 2. |
Frodin, M. and Gammeltoft, S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol. Cell. Endocrinol. 151, 65 |
| 3. |
Lazar, D. F. et al. Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin. J. Biol. Chem. 270, 20801 |
| 4. |
Chen, R. et al. Phosphorylation of the c-Fos Transrepression Domain by Mitogen-Activated Protein Kinase and 90-kDa Ribosomal S6 Kinase. Proc. Natl. Acad. Sci. USA, 90, 10952 |
Orders:
877-772-2622 (US and Canada)
650-583-6688 (Domestic and International)
orders@epitomics.com
Technical Support: support@epitomics.com
Product MSDS: view page or download PDF
*Determined species reactivity – for other species not listed cross reactivity
may be possible but not tested. |
