Clone ID: EP1039Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 1812-1
Size: 100ul
Price: $ 250
Recommended Applications: WB, IHC, ICC, IP
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 75 kDa
UniProt ID: P08138
Alternative names: Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, CD271 antigen
Description: Neurotrophins signal cell survival, differentiation, growth cessation, and apoptosis through two classes of cell surface receptors, the Trks and NGF Receptor (p75NTR). p75NTR, when activated in the absence of a strong Trk signal, induces apoptosis of neurons, while in the presence of Trk it enhances responses to neurotrophin (1). p75NTR, when it is not bound by NGF, may play a role in neuronal selection during embryonic development and suggest that neuroblastomas may arise from immature neuroblasts that escape programmed cell death. Therefore, the loss of p75NTR expression in developing neural crest cells might be a primary event in the genesis of neuroblastoma (2). It has also been suggested that neuronal death in Alzheimer's disease is mediated, at least in part, by the interaction of beta-amyloid with p75NTR, and suggest new targets for therapeutic intervention (3). Specificity: A synthetic peptide corresponding to residues of human NGFR was used as an immunogen.
Recommended Dilutions:
WB: 1:2,000-50,000
IHC: 1:50 100
ICC: 1:50
IP: 1:50
Protocols for using Epitomics Rabbit Monoclonal Antibodies
|
 |
| A. Western blot analysis on PC12 cell lysate using anti-NFGR RabMAb (cat. # 1812-1), dilution 1:50,000 |
B. Immunohistochemical staining of paraffin-embedded human brain gilioma using anti-NFGR RabMAb (cat. # 1812-1). |
Description References:
| 1. |
Kaplan DR, et al. Curr Opin Cell Bio 9(2):213-21, 1997 |
| 2. |
Bunone G, et al. Oncogene 14(12):1463-70, 1997 |
| 3. |
Yaar M, et al. J Clin Invest 100(9):2333-40, 1997 |
Orders:
877-772-2622 (US and Canada)
650-583-6688 (Domestic and International)
orders@epitomics.com
Technical Support: support@epitomics.com
Product MSDS: view page or download PDF
*Determined species reactivity – for other species not listed cross reactivity
may be possible but not tested. |
