In Vitro Diagnostics
Size: 1ml, Format: Concentrate
The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer.
In a recent assessment conducted by NordicQC, Epitomics antibody to Mismatch Repair Protein MSH6 (Clone EP49) was rated "Optimal" against a panel of 15 other vendor antibodies. See the full comparison test here.