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In Vitro Diagnostics


Cytokeratin 4Cat.#: AC-0011

Clone ID: EP4
Classification: IVD
Size: 1ml, Format: Concentrate


Cytokeratin 4 (CK4) is a 59 kDa intermediate filament protein associated with cytokeratin 13. It is expressed in suprabasal cells of non-keratinized stratified squamous epithelium of esophagus, cornea, anus, larynx, pharynx and tongue. A mutation in CK4 gene causes white sponge nevus. A decreased expression of CK4 is associated with head and neck squamous carcinoma. It is helpful in differentiation of squamous cell carcinoma of esophagus origin from thyroid origin.