In Vitro Diagnostics
Size: 1ml, Format: Concentrate
Ribonucleoside-diphosphate reductase large subunit (RRM1) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Studies have shown that RRM1 controls cell proliferation through deoxynucleotide production and metastatic propensity through PTEN induction. RRM1 expression is significantly correlated with the expression of ERCC1 and PTEN in non-small-cell lung cancer (NSCLC). Tumors with high expression of RRM1 showed slow progression.